In the article that accompanies this editorial, Rahman et al 2 describe the results from the first three experimental arms of the INSIGhT trial which, to our knowledge, is the first adaptive platform ...

The following represents disclosure information provided by the authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless ...

Professor Yeonhee Park of the Department of Statistics at Sungkyunkwan University has developed a novel statistical framework — MARGO (Machine Learning-Assisted Adaptive Randomization for Group ...

An innovative phase 2 clinical trial designed to find new potential treatments for glioblastoma has reported initial results. While none of the three therapeutics tested so far improved overall ...

As for whether the trial established that simvastatin is beneficial, the trial was stopped early because of a low likelihood of reaching prespecified stopping criteria, as a result of decreasing ...

Randomization have proven to be an efficient way of reducing bias and thus is widely used in clinical trials. Randomization ensures that subject allocation is balanced across treatment group and is ...