The complement system is a diverse set of proteins long known for its association with innate immunity. Recent decades have demonstrated novel location and roles for key complement proteins in the ...

The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or ...

For the complement system to cause AMD, there must be initiation (a ‘trigger’), amplification, and local retinal damage caused by the process. The alternative pathway of the complement system is ...

Complement molecules are the immune proteins responsible for identifying bacteria, viruses, and other foreign invaders as they circulate through our bodies. Their function helps lymphocytes to locate ...

To survive in the human host, bacteria have developed many different strategies to escape the innate immune response, including the expression of an extracellular capsule and 'hiding' within host ...

Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven ...

PHOENIX, Arizona—Nipocalimab might lower the concentration of anti-acetylcholine receptor antibodies, or anti-AChR antibodies, in people with generalized myasthenia gravis, reducing neuromuscular ...

Background Anti-C1q autoantibodies can disrupt normal complement function, contributing to the formation of pathogenic immune complexes and end-organ damage. Although their role in SLE is ...

ARVO presenters conducted a retrospective study to assess the visual and anatomical outcomes of patients receiving complement inhibitors for geographic atrophy. In a real-world cohort of patients with ...