We oriented the clusters by their lesion-containing strand, and designated the first mutation site to be replicated over on the lesion-containing template as the upstream (5′) mutation and subsequent ...

DNA damage is a threat to genome integrity and can be a cause of many human diseases, owing to either changes in the chemical structure of DNA or conversion of the damage into a mutation, that is, a ...

DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell divides—whether to repair damaged tissue, replace old cells, or simply to help the ...