In all living organisms, proliferating cells go through the fundamental process of DNA replication. Through this process, they faithfully duplicate their DNA and divide into two daughter cells. In ...

DNA replication initiation requires local melting of fully base-paired DNA for a helicase to gain a foothold and initiate processive DNA unwinding. In eukaryotes and archaea, the helicase engine is ...

Copy number variants (CNVs) are strongly implicated in neurological and psychiatric disorders and brain cancer, yet the process by which replication stress generates CNVs—and why some recur while ...

Researchers studying mice have uncovered a surprising period of genomic instability in embryonic development, with implications for fertility treatments and genetic ...

Scientists uncovered DNA's double helix structure in 1953. James Watson and Francis Crick proposed the model. It explained ...