Thousands of RNA-binding proteins (RBPs) crosslink to cellular mRNA. Among these are numerous unconventional RBPs (ucRBPs)—proteins that associate with RNA but lack known RNA-binding domains (RBDs).

The large-scale analysis of small-molecule binding to diverse RNA structures is key to understanding the required interaction properties and selectivity for developing RNA-binding molecules toward RNA ...

This article and associated images are based on a poster originally authored by Adam Buckle, Julia Unsicker and Iain McWilliam and presented at ELRIG Drug Discovery 2025 in affiliation with Arrayjet ...