Nature

Predictors of next-generation sequencing panel selection using a shared decision-making approach

While there is great optimism for NGS panel testing, there are still a number of limitations to be considered. In addition to high-penetrance genes, NGS panels typically include a mixture of moderate- ...
Medical Xpress

Is comprehensive genetic testing worth it for patients with cancer?

Comprehensive gene panel testing, one of the exciting new tools in cancer diagnostics, warrants greater scrutiny—as does a federal program aimed at speeding up the review process for proposed new ...
Nature

Germline FFPE inherited cancer panel testing in deceased family members: implications for clinical management of unaffected relatives

In the United Kingdom (UK), recommendations for the care of individuals with a family history of breast cancer are detailed in the National Institute for Health and Care Excellence (NICE) guidance [1] ...
ascopubs.org

Clinical Utility of Tumor Next-Generation Sequencing Panel Testing to Inform Treatment Decisions for Patients With Advanced Solid Tumors in a Tertiary Care Center

Real-World Impact of an In-House Dihydropyrimidine Dehydrogenase (DPYD) Genotype Test on Fluoropyrimidine Dosing, Toxicities, and Hospitalizations at a Multisite Cancer Center Of the 582 surveys sent, ...
ascopubs.org

Underdiagnosis of Hereditary Breast Cancer: Are Genetic Testing Guidelines a Tool or an Obstacle?

An estimated 10% of breast and ovarian cancers result from hereditary causes. Current testing guidelines for germ line susceptibility genes in patients with breast carcinoma were developed to identify ...