Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

Single-cell RNA transcriptomics allows researchers to broadly profile the gene expression of individual cells in a particular tissue. This technique has allowed researchers to identify new subsets of ...

Capturing spatial information is essential to elucidate how cells function and interact within their native tissue environment. However, the initial spatial transcriptomics techniques have several ...

A team of researchers has constructed the most detailed single-cell map of the adult human prostate to date, cataloging more ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

Single-cell proteomics is transforming the study of cell heterogeneity by enabling protein-level analysis in individual cells. In contrast to bulk proteomics, single-cell proteomics captures ...

While such advances bring with them a breadth of knowledge, the immense complexity of the datasets makes it challenging for scientists to analyze them using current computational methods. Now, ...

Andreas Pfenning discusses the techniques being developed and used to study neuronal heterogeneity and the therapeutic potential of his work.