Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

Single-cell RNA transcriptomics allows researchers to broadly profile the gene expression of individual cells in a particular tissue. This technique has allowed researchers to identify new subsets of ...

A wave of spatial transcriptomics studies has produced gene-expression atlases that span entire organs and whole organisms, ...

Capturing spatial information is essential to elucidate how cells function and interact within their native tissue environment. However, the initial spatial transcriptomics techniques have several ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

A team of researchers has constructed the most detailed single-cell map of the adult human prostate to date, cataloging more ...

Single-cell proteomics is transforming the study of cell heterogeneity by enabling protein-level analysis in individual cells. In contrast to bulk proteomics, single-cell proteomics captures ...

Andreas Pfenning discusses the techniques being developed and used to study neuronal heterogeneity and the therapeutic potential of his work.

A new single-cell atlas shows how epigenetic changes reshape brain cells during aging, revealing genomic instability, ...