Retroviral integration into host cell chromosomes was once thought to be random, but new evidence suggests that human immunodeficiency virus preferentially enters the neighborhood of activated genes.

Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we report a ...

Lentiviral vector mobilization following HIV-1 infection of vector-transduced cells poses biosafety risks to vector-treated patients and their communities. The self-inactivating (SIN) vector design ...