A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) ...
Retroviral vector gene therapy offers immense potential to treat many genetic diseases 1 and has shown efficacy in clinical trials 2,3,4. The joint SCID-X1 trial between Paris and London demonstrated ...
Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we report a ...
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